Thesis

About

Thesis is an AI research lab automating AI R&D itself. We are building Darwin, a hill-climbing machine capable of searching vast combinatorial spaces of experiments. By using the outcome of every experiment to optimize the next, Darwin turns machine learning research into a compounding system rather than a sequence of manual attempts. We are directing this machine toward the grand challenges of biology and materials science. Our mission is to build the machine that discovers the next Transformer, the next AlphaFold, and the breakthroughs that push science and engineering to the absolute frontier.

Founders

• 
  Sergio Charles· Co-Founder & CEO

  Thesis will automate AI research. Maximally truth-seeking. Prev: AI R&D at Google X, Nvidia and Stanford's AI Lab, working with Andrew Ng and Chelsea Finn. B.S. Math & CS, M.S. Stats Stanford

  LinkedIn ↗
• 
  Luigi Charles· Founder

  Betting the farm that AI will become meaningful in the discovery of new science. Second time founder. Previously scaled stablecoin payments infrastructure from zero to billions. Columbia CS & Math.

  LinkedIn ↗

Product launches · 1 launch

• δ Thesis: Building the frontier of AI discovery ↗▲ 232Nov 11, 2025

  Making it possible for researchers anywhere to discover the next Transformer or invent the next AlphaFold.

Change history · 10 recorded

1. July 25, 2026
   • Tags updated07:00 PM
   • Description rewritten07:00 PM
2. July 12, 2026
   • Description rewritten07:00 PM
   • Tags updated07:00 PM
3. June 27, 2026
   • Tags updated07:00 PM
4. June 10, 2026
   • Started hiring07:00 PM
5. June 9, 2026
   • Tags updated07:00 PM
   • Team grew from 2 to 307:00 PM
6. June 2, 2026
   • Pitch updated07:00 PM
   • Description rewritten07:00 PM